SWAMNA: a comprehensive platform for analysis of nucleic acid modifications

05 September 2023, Version 1

Abstract

The interest in MS-based analysis of modified nucleic acids is increasing due to the application of nucleic acids in therapeutics. However, there are few available integrated platforms for characterizing nucleic acid modifications. Herein, we report a general mass spectrometry-based SWATH platform to identify and quantify both RNA and DNA modifications, which we call SWATH Analysis of Modified Nucleic Acids (SWAMNA). SWAMNA incorporates the search engine, NuMo Finder, enabling the analysis of modifications in native and permethylated form. SWAMNA will aid discoveries that provide new insights into nucleic acid modifications.  

Keywords

Nucleic Acid Modification
RNA Modification
DNA Modification

Supplementary materials

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Description
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Supplementary Information 1
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Method details and Supplementary Figures
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Supplementary Information 2
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Instructions for using NuMo Finder
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