Rapid Automated Iterative Small Molecule Synthesis

04 September 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Automated iterative small molecule synthesis has the potential to advance and democratize the discovery of new medicines, materials, and many other classes of functional chemical matter. But to date this approach has been limited by a requirement of about one day of time per C-C bond forming step. Here, we report a nextgeneration small molecule synthesizer which operates at an order of magnitude faster than prior systems through improvements in both chemistry and engineering. These findings move the field of small molecule synthesis a step closer to democratizing its core discovery engine.


Small Molecules
Synthetic Platform
Rapid Synthesis
Automated Synthesis

Supplementary materials

Rapid Automated Iterative Small Molecule Synthesis Supporting Information
Experimental detail and spectra for Rapid Automated Iterative Small Molecule Synthesis


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.