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Unlocking the Chain-Walking Process in Gold Catalysis

30 August 2023, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The successful realization of gold-catalyzed chain-walking reactions, facilitated by ligand-enabled Au(I)/Au(III) redox catalysis, has been reported for the first time. This breakthrough has led to the development of gold-catalyzed annulation reaction of alkenes with iodoarenes by leveraging the interplay of chain-walking and π-activation reactivity mode. The reaction mechanism has been elucidated through comprehensive experimental and computational studies.

Keywords

Gold catalysis
Chain-walking
Migratory insertion
β-hydride elimination
Annulation

Supplementary materials

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Version History

Aug 30, 2023 Version 2

Version Notes

The manuscript has been restructured.

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-bzz0k-v2
D O I: 10.26434/chemrxiv-2023-bzz0k-v2 [opens in a new tab]

Funding

SERB, New Delhi
CRG/2022/000195 and SCP/2022/000063

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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