Unlocking the Chain-Walking Process in Gold Catalysis

30 August 2023, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The successful realization of gold-catalyzed chain-walking reactions, facilitated by ligand-enabled Au(I)/Au(III) redox catalysis, has been reported for the first time. This breakthrough has led to the development of gold-catalyzed annulation reaction of alkenes with iodoarenes by leveraging the interplay of chain-walking and π-activation reactivity mode. The reaction mechanism has been elucidated through comprehensive experimental and computational studies.

Keywords

Gold catalysis
Chain-walking
Migratory insertion
β-hydride elimination
Annulation

Supplementary materials

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