Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

C–H Alkylation of Cubanes via Polar Effect-Assisted Photocatalytic Generation of Cubyl Radicals

17 August 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A method for C–H alkylation of cubanes is described herein. A hydrogen atom–transfer catalyst enables direct abstraction of a hydrogen atom from the C–H bond of cubanes, followed by conjugate addition of the generated cubyl radicals to various Michael acceptors. Synthetic applications of the developed functionalization method are also described.

Keywords

cubane
C–H functionalization
hydrogen atom transfer catalyst

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Aug 17, 2023 Version 1

Metrics

1,179
713
1
Views
Downloads

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-s8fkr
D O I: 10.26434/chemrxiv-2023-s8fkr [opens in a new tab]

Funding

Japan Society for the Promotion of Science
JP21K15218, JP23K14315
The Tokyo Biochemical Research Foundation
Teijin Pharma Award in Synthetic Organic Chemistry, Japan
Japan Agency for Medical Research and Development
JP22ama121040j0001

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share