C–H Alkylation of Cubanes via Polar Effect-Assisted Photocatalytic Generation of Cubyl Radicals

17 August 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A method for C–H alkylation of cubanes is described herein. A hydrogen atom–transfer catalyst enables direct abstraction of a hydrogen atom from the C–H bond of cubanes, followed by conjugate addition of the generated cubyl radicals to various Michael acceptors. Synthetic applications of the developed functionalization method are also described.


C–H functionalization
hydrogen atom transfer catalyst


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