Construction of Si-Stereogenic Silanols via Enantioselective Pd-Catalyzed C–H Alkenylation

The construction of silicon-stereogenic silanols via the Pd-catalyzed intermolecular C–H alkenylation with the assistance of a commercially available L-pyroglutamic acid has been realized for the first time. Employing the oxime ether as the directing group, the silicon-stereogenic silanol derivatives could be readily prepared with excellent enantioselectivities, featuring a broad substrate scope and good functional group tolerance. Mechanistic studies indicate that L-pyroglutamic acid could stabilize the Pd catalyst and provide excellent chiral induction. Preliminary computational studies unveil the origin of the enantioselectivity in the C–H bond activation step.