Harnessing Croconaine Organic Photosensitizers for a Milder Surface-Mediated Transfection

07 August 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Polydopamine-based materials, notably Polydopamine-polyethyleneimine (PDA-PEI), have gained considerable interest for surface-mediated transfection. However, the high laser power density required to achieve high transfection efficiency poses a significant challenge in preserving cell viability. An organic photosensitizer CRO32TMI was developed to improve the photothermal conversion capability of PDA-PEI. The modified PDA-PEI-CRO32TMI exhibited remarkable photothermal and photostability properties upon NIR irradiation, enabling it to achieve better transfection efficiency at lower laser power density as compared to the traditional solution or lipid-based transfection methods.

Keywords

organic photosensitizer
photothermal
transfection

Supplementary materials

Title
Description
Actions
Title
Supplementary Information
Description
Supplementary Information
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.