Ni-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers

Gabriele  Laudadio; Philipp Neigenfind; Áron Péter; Megan A. Emmanuel; Maximilian D. Palkowitz; Martins S. Oderinde; Jack L. Sloane; Kevin W. Gillman; Daniel Ridge; Philippe Bolduc; Michael Nicastri; Benxiang Zhang; Sebastian Clementson; Nadia Nasser Petersen; Pablo Martín- Gago; Pavel Mykhailiuk; Michael A. Schmidt; Michael D. Mandler; Phil S. Baran

doi:10.26434/chemrxiv-2023-srlm6

Organic Chemistry

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Ni-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers

25 July 2023, Version 1

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Abstract

There is an urgent need, particularly in the field of drug discovery, for general methods that will enable direct coupling of tertiary alkyl fragments to (hetero)aryl halides. This early disclosure serves this purpose by informing the community of a uniquely powerful and simple set of conditions for achieving this transformation with unparalleled generality and chemoselectivity.

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Version History

Sep 04, 2023 Version 2

Jul 25, 2023 Version 1

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DOI

10.26434/chemrxiv-2023-srlm6

Funding

NSF Center for Synthetic Organic Electrochemistry

CHE-2002158

George E. Hewitt Foundation Postdoctoral Fellowship

Kellogg Family Fellowship

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The author(s) have declared they have no conflict of interest with regard to this content

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The author(s) have declared ethics committee/IRB approval is not relevant to this content

Ni-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers

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