Pd-Catalyzed picolinamide directed late-stage chalcogenation of tryp-tophan containing peptides

13 July 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This report describes the Pd-catalyzed late-stage chalcogenation of tryptophan containing peptides with disulfides/diselenides in moderate to good yields. It comprises broad substrate scope, functional group diversity, late-stage mutation of drug mole-cules and various valuable synthetic transformations including room temperature easy removal of picolinamide auxiliary, which could be applicable to tune the structure and function of peptides.

Supplementary materials

Title
Description
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Title
Pd-Catalyzed picolinamide directed late-stage chalcogenation of tryp-tophan containing peptides
Description
NMR, HRMS and X-ray spectra data
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