Short, Scalable Access to Pyrrovobasine

12 July 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A concise, gram-scale synthesis of pyrrovobasine (1) is reported. Key transformations include a 3-step decagram-scale synthesis of the tetracyclic compound without protecting groups, Mn-mediated direct radical cyclization, and introducing a naturally rare pyrraline structure. The synthesis is designed to be applicable to gram-scale synthesis using inexpensive and readily available reagents.


Total synthesis
short-step synthesis
Alkaloid synthesis

Supplementary materials

Supporting Information
Experimental Procedures and Characterization of Compounds


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