Protecting Group-Free Synthesis of the Antimalaria Drug MMV693183

13 July 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

MMV693183 is a promising antimalarial drug candidate that works for uncomplicated malaria treatment and resistance management. Herein, we report an efficient and highly regioselective synthesis of MMV693183. This efficient approach to MMV693183 is only three steps from readily available starting materials and provides the API in 46 % overall yield without requiring protecting groups.

Keywords

MMV693183
antimalaria
regioselective synthesis
protecting group free
API

Supplementary materials

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Supporting Information
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These data include experimental details, characterization data, analytical methods and copies of NMR spectra.
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