Serum Amine Profiling through Fluorine-Labeled 19F NMR Analysis

11 July 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We present a novel approach utilizing 19F-nuclear magnetic resonance (NMR) spectroscopy for serum amine profiling. Our method introduces a highly efficient and reliable technique for fluorine labeling of amine metabolites via Schiff base formation. By employing this fluorine labeling, we successfully achieve accurate identification and quantification of amine metabolites in human serums, providing valuable insights for metabolomics research.

Keywords

Amino Acids
Human serum
19F NMR
Metabolite analysis

Supplementary materials

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Supporting Information
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Experimental details and spectral data
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