Unlocking diabetic acetone vapor detection by a portable metal-organic framework-based optical sensor device

10 July 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Despite exhaled human breath having enabled noninvasive diabetes diagnosis, selective acetone vapor detection by fluorescence approach in the diabetic range (1.8-3.5 ppm) remains a long-standing challenge. We report a set of water-resistant luminescent metal-organic framework (MOF)-based composites for detecting acetone vapor in the diabetic range with a limit of detection of 200 ppb. The luminescent materials can also detect acetone vapor selectively unimpeded by excessive water vapor and other competing VOCs mixture, and it can be reused in minutes under ambient conditions. Industrially pertinent electrospun unique luminescent fibers were likewise fabricated alongside various luminescent films for selective detection of ultratrace quantities of acetone vapor present in the air. Ab initio theoretical calculations combined with in situ synchrotron-based dosing studies uncovered the material’s remarkable hypersensitivity towards acetone vapor. Finally, a freshly designed prototype fluorescence-based portable optical sensor was utilized for the rapid detection of acetone vapor within the diabetic range.


Acetone sensing
metal-organic frameworks
optical sensors

Supplementary materials

Supplementary Information
Materials characterization and physical measurement techniques, Density functional theory (DFT) calculations


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