Shape-Assisted Self-Assembly of Hexa-Substituted Carpyridines into 1D Supramolecular Polymers

07 July 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The role that molecular shape plays on the self-assembly of supramolecular polymers remains an open question in the field. We began addressing this fundamental question with the introduction of “carpyridines”, which are saddle-shaped monomers that can associate with one another through pi-pi interactions and in which the rotational and translational movements are restricted. The topography displayed by the monomers permits the assembly of highly ordered 2D materials even in the absence of strong directional interactions such as hydrogen bonding. Here, we introduce a simple strategy to gain control over the dimensionality of the formed structures yielding classical unidimensional polymers. These have been characterized using established protocols allowing us to determine and confirm the self-assembly mechanism of both fibers and 2D sheets. Fascinatingly, the calculated interaction energies are significantly higher than expected for a self-assembling system lacking “strong” non-covalent interactions. The versatility of this supramolecular unit to assemble into either supramolecular fibers or 2D sheets with strong association energies highlights remarkably well the potential and importance of molecular shape for the design of supramolecular materials and the applications thereof.


Supramolecular polymers
shape-assisted self-assembly
polyaromatic topography
non-covalent synthesis

Supplementary materials

Supplementary Info
Additional Datasets


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