Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation

16 June 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Stimuli-responsive hydrogels are intriguing biomimetic materials. Previous efforts to develop mechano-responsive hydrogels have mostly relied on chemical modifications of the hydrogel structures. Here, we present a simple, generalizable strategy that confers mechano-responsive behavior on hydrogels. Our approach involves embedding hybrid vesicles, composed of phospholipids and amphiphilic block copolymers, within the hydrogel matrix to act as signal transducers. Under mechanical stress, these vesicles undergo deformation and rupture, releasing encapsulated compounds that can control the hydrogel network. To demonstrate this concept, we embedded vesicles containing ethylene glycol tetraacetic acid (EGTA), a calcium chelator, into a calcium-crosslinked alginate hydrogel. When compressed, the released EGTA sequesters calcium ions and degrades the hydrogel. This study provides a novel method for engineering mechano-responsive hydrogels that may be useful in various biomedical applications.


Stimuli-Responsive Hydrogel
Functional Material
Stress-Induced Degradation
Block copolymers

Supplementary materials

Supporting Information
Experimental Details and Supplementary Figures


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Comment number 1, Sung-Won Hwang: Nov 16, 2023, 21:28

Published: https://doi.org/10.1002/anie.202308509