Diastereo- and Enantioselective Palladium-Catalyzed Cycloadditions of 5-Vinyloxazolidine-2,4-diones with Electrophilic Imines

08 June 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Despite the importance of the 4-imidazolidinone scaffold in bioactive compounds or organocatalysts, methodologies to access these nitrogenated heterocycles remain scarce. This manuscript describes a novel preparation of 4-imidazolidinones via a diastereo- and enantioselective (3+2) cycloaddition between 5-vinyloxazolidine-2,4-diones (VOxD) and electrophilic imines under palladium catalysis. This work supports the synthetic potential of VOxD as promising equivalents of the C–C(=O)–N synthon.


organometallic catalysis
palladium catalysis

Supplementary materials

Supporting Information
Experimental procedures and NMR spectra for all new compounds


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