Radical Group Transfer of Vinyl and Alkynyl Silanes Driven by Photoredox Catalysis

02 June 2023, Version 1


Radical group transfer is a powerful tool for the formation of C–C bonds. These processes typically involve radical addition to C–C π bonds, followed by fragmentation of the cyclic intermediate. Despite the advantageous lability of organosilanes in this context, silicon-tethered radical acceptor groups have remained underexplored in radical group transfer reactions. We report a general photoredox-catalyzed protocol for the radical group transfer of vinyl and alkynyl silanes onto sp3 carbons, using activated and unactivated iodides as radical precursors. Our method displays high diastereoselectivity and excellent functional group tolerance. Mechanistic investigations revealed the key role played by silicon in facilitating a single-electron oxidation step, which leads to direct ring-opening and an overall redox-neutral process.


Supplementary materials

Supplementary Information
Supplementary experiments, synthesis and characterization of substrates, NMR spectra.

Supplementary weblinks

Raw data
Compound characterization data, including 1H and 13C NMR, 2D NMR, IR, HRMS.


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