Rose Bengal Promoted Catalytic Amyloid-β Oxygenation via Sono-Activation

30 May 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Catalytic photo-oxygenation of amyloid-β is a leading therapeutic strategy for the treatment of Alzheimer disease. However, the limited tissue-permeability of light hampers its clinical application. We here report an alternative catalytic sono-oxygenation strategy to circumvent this problem. Amyloid-β aggregates were oxygenated using rose bengal as a sonosensitizer under ultrasound irradiation. Structure-activity relationships revealed that xanthene-derived catalysts containing halogen atoms furnished superior amyloid oxygenation activity.


Alzheimer disease
amyloid oxygenation
sonodynamic therapy


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.