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Abstract
Catalytic photo-oxygenation of amyloid-β is a leading therapeutic strategy for the treatment of Alzheimer disease. However, the limited tissue-permeability of light hampers its clinical application. We here report an alternative catalytic sono-oxygenation strategy to circumvent this problem. Amyloid-β aggregates were oxygenated using rose bengal as a sonosensitizer under ultrasound irradiation. Structure-activity relationships revealed that xanthene-derived catalysts containing halogen atoms furnished superior amyloid oxygenation activity.
