Self-assembling materials mimicking dynamic bio-interfaces in cellular activities

25 May 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


This article focuses on recent studies of the development of bioinspired supramolecular materials mimicking the contact events seen at the dynamic bio-interfaces. A diverse range of cellular activities occurs through the dynamic actions of biomacromolecules and supramolecular assemblies such as extracellular matrices, phospholipid bilayers, and membrane proteins that construct the interfaces between and within cells. Mimicking their dynamic actions seen at the bio-interfaces can be an effective approach to developing biomaterials applicable to regenerative medicine and drug delivery systems. Rapid progress in supramolecular chemistry and nanotechnology has made it possible to construct and functionalize various bio-interfaces with dynamic natures. In this article, the construction of artificial extracellular matrices and membrane-deforming supramolecular materials is highlighted with their applications to injured brain regeneration and in vivo cargo delivery for extended blood circulation.


Supramolecular polymer
Extracellular matrix
Membrane deformation


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