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Application of AlphaFold on metamorphic proteins

19 May 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

AlphaFold - a game changer for accurate protein structure prediction was tested on metamorphic proteins, which display two or more distinct folds while having the same sequence. We highlighted the limitations of the method and suggested careful investigation of obtained models.

Keywords

AlphaFold
metamorphic
proteins

Supplementary materials

Title
Description
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Title
Supplementary Materials
Description
Supplementary Tables S1 - S2, Supplementary Figures S1 - S16
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Version History

May 19, 2023 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-4nlrs
D O I: 10.26434/chemrxiv-2023-4nlrs [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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