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BHAS Coupling of Aryl Halides to Arenes Facilitated by Nickel Complexes

16 May 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Aryl halides are efficiently coupled to benzene using air-stable Ni(COD)(DQ) (COD = 1,5-cyclooctadiene, DQ = duroquinone) and KOtBu, without additional ligands. Mechanistic evidence suggests that Ni(COD)(DQ) and KOtBu act as an initiation source, forming aryl radicals that then react with the arene via base-assisted homolytic aromatic substitution.

Keywords

Ni(COD)(DQ)
coupling
BHAS
radical
KOtBu

Supplementary materials

Title
Description
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Title
SI for "BHAS Coupling of Aryl Halides to Arenes Facilitated by Nickel Complexes"
Description
Spectroscopic and Chromatographic supplementary information
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Version History

May 16, 2023 Version 1

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License

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The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-z112p
D O I: 10.26434/chemrxiv-2023-z112p [opens in a new tab]

Funding

EPSRC
GSK

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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