Asymmetric Synthesis of Unnatural α-Amino Acids through Photoredox-Mediated C–O Bond Activation of Aliphatic Alcohols

15 May 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


An efficient protocol for the asymmetric synthesis of unnatural amino acids is realized through photoredox-mediated C–O bond activation of oxalate esters derived from aliphatic alcohols as the radical precursors. The developed system uses chiral glyoxylate-derived N-sulfinyl imine as the radical acceptor and allows quick access to a range of functionalized unnatural amino acids through an atom-economical redox-neutral process with CO2 as the only stoichiometric by-product.


amino acids
photoredox catalysis
stereoselective synthesis

Supplementary materials

Supplementary Information
Experimental procedures, characterization data, and copies of NMR spectra


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