Cu(III) Trifluoromethyl Complexes with 1,3-Diketonate Ligands and Their Versatile Reactivity in C-H Trifluoromethylation

11 May 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


High-valent Cu(III) trifluoromethyl complexes with 1,3-diketonates as bidentate oxygen donor ligands LCuIII(CF3)2 were prepared for the first time and fully characterized, including X-ray crystallography. These complexes are soluble in most organic solvents and were found to be more reactive than known N-donor Cu(III) trifluoromethyl complexes. They exhibit a promising reactivity in radical and radical-polar crossover trifluoromethylation reactions. Direct C-H trifluoromethylation of electron-rich arenes and indoles using Cu(III) trifluoromethyl diketonates under blue light irradiation in mild conditions is described. Azolo- and oxy-trifluoromethylation of terminal alkynes using Cu(III) trifluoromethyl diketonate complex and S-trifluoromethylation of thiophenol were demonstrated as applications.


High-valent copper
C-H activation

Supplementary materials

Supplementary information
Experimental procedures, characterization data of new compounds, UV-vis absorbance spectra, copies of NMR spectra.


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