Arenes and Heteroarenes C–H Functionalization Under Enabling Conditions: Electrochemistry, Photoelectrochemistry & Flow Technology

08 May 2023, Version 2
This content is a preprint and has not undergone peer review at the time of posting.


C-H bond functionalization generates molecular complexity in single-step transformation. However, the activation of C-H bonds requires expensive metals or stoichiometric amounts of oxidizing/reducing species. In many cases, they often require pre-functionalization of starting molecules. Such pre-activating measures cause waste generation and their separation from the final product is also troublesome. In such a scenario, reactions activating elements generating from renewable energy resources such as electricity and light would be more efficient, green, and cost-effective. Further, incorporation of growing flow technology in chemical transformation processes will accelerate the safer accesses of valuable products. Arenes & (hetero) arenes are ubiquitous in pharmaceuticals, natural products, medicinal compounds, and other biologically important molecules. Herein, we discussed enabling tools and technologies used for the recent C–H bonds functionalization of Arenes / (Hetero)Arenes.


C–H functionalization
Flow electrosynthesis
Green Chemistry
Sustainable Chemistry
Arenes / (Hetero)Arenes C–H Functionalization
Synergistic Chemistry

Supplementary weblinks


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