Cu(II)-Catalyzed Aerobic Synthesis of Sulfinamidines from Sulfenamides

19 April 2023, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Inhere, the first instance of copper-catalyzed oxidative amination of sulfenamides for the synthesis of sulfinamidines was documented. Employing air as the terminal oxidant, a variety of secondary and primary amines can be effectively transformed into their target products. This reaction boasts excellent chemoselectivity, mild conditions, straightforward operation, and broad substrate compatibility, which has significant implications for the fields of pharmaceuticals and organic synthesis.

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