Limonene as natural product extraction solvent

13 April 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


First reported in 2004, and subsequently advanced by Chemat’s and other research teams in the following two decades, the use of d-limonene as natural product extraction solvent offers multiple benefits that go beyond its environmentally benign nature. Following a review of the main research achievements concerning the use of this biosolvent in the extraction of widely different natural products, we offer a comprehensive perspective including usually neglected economic and safety aspects.


Natural product
Green extraction
Circular economy


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