Vernonia amygdalina Extract Reverts Hematological and Biochemical Alterations in Rats Exposed to N-Nitroso-N-ethyl urea

04 April 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


35 Sprague Dawley rats were exposed to carcinogen and treated with different concentrations of Vernonia amygdalina aqueous extracts. 3 doses of 50mg/kg doses of N-Nitroso-N-ethyl urea (NEU) was given intraperitoneally at two weeks interval. Changes in hematological and biochemical parameters were determined in blood and serum samples. NEU exposed rats treated group showed significant alterations in several hematological and biochemical parameters. In comparison to the control group, the carcinogen exposed rats showed significantly increased Blood Glucose, Serum Total Cholesterol: Low Density Lipoprotein (LDL-Cholesterol), Triacylglycerol's levels and High Density Lipoprotein (HDL-Cholesterol) level. After treatment with V. amygdalina aqueous extract, hematological and biochemical parameters in the carcinogen exposed rats treated group were approximately similar to control group. The V. amygdalina extract significantly restored the hematological and biochemical parameters in N-Nitroso-N-ethyl urea carcinogen exposed rats


Vernonia amygdalina
N-Nitroso-N-ethyl urea
hematological parameters
biochemical parameters


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