Direct Alkylative Reductive Amination using 1-Allylsilatrane

29 March 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Homoallylic amines prepared via addition of allylsilanes often require preformed imine substrates, metal catalysts, fluoride activators, or use of protected amines. In this metal-free, air- and water-tolerant procedure, aromatic aldehyde and aniline substrates undergo direct alkylative reductive amination using easily accessible 1-allylsilatrane.

Keywords

silanes
reductive amination
three-component coupling

Supplementary materials

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Supporting Information
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Experimental procedures, characterization data and images.
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