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Direct Alkylative Reductive Amination using 1-Allylsilatrane

29 March 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Homoallylic amines prepared via addition of allylsilanes often require preformed imine substrates, metal catalysts, fluoride activators, or use of protected amines. In this metal-free, air- and water-tolerant procedure, aromatic aldehyde and aniline substrates undergo direct alkylative reductive amination using easily accessible 1-allylsilatrane.

Keywords

silanes
reductive amination
three-component coupling

Supplementary materials

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Supporting Information
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Experimental procedures, characterization data and images.
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Version History

Mar 29, 2023 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-2q6df
D O I: 10.26434/chemrxiv-2023-2q6df [opens in a new tab]

Funding

NSERC
Toronto Metropolitan University

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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