Effects of Senna alata Extract on the Hematological and Biochemical Alterations in Rats Exposed to Carcinogen

29 March 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


ABSTRACT: A total of 35 female albino rats were divided into 7 groups: control, rats exposed to carcinogen, treated with varying concentrations of Senna alata plant aqueous extracts, treated with standard drug, and untreated for total 28 days of treatment.. Freshly prepared 3 fractionated doses of 50mg/kg N-Nitroso-N-ethyl urea (carcinogen) dissolved in 1/15M Phosphate buffer was given intraperitoneally at average ages 50, 65 and 80 days. At the end of the test period, hematological and biochemical parameters were determined in blood and serum samples with determination of body weights. The body weights were significantly affected in carcinogen exposed rats as compared to control rats. Compared to the control group, the carcinogen exposed rats treated group showed significances in several hematological parameters, including decreases in White blood cell (WBC), Red blood cell (RBC), and Platelet (PLT) counts. Furthermore, in comparison to the control group, the carcinogen exposed rats showed significantly increased blood glucose, serum total cholesterol, Low density lipoprotein (LDL-cholesterol), triacylglycerols levels and High density lipoprotein (HDL-cholesterol) level. The hematological and biochemical parameters in the carcinogen exposed rats treated group were approximately similar to control group. The S.alata extract significantly restored the hematological and biochemical parameters in N-Nitroso-N-ethyl urea carcinogen exposed rats


Senna alata
N-Nitroso-N-ethyl urea
natural product
hematological and biochemical parameters


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.