Palladium-Catalyzed Enantioselective Three-Component Synthesis of alpha-Arylglycine Derivatives from Glyoxylic Acid, Sulfonamides and Aryl Trifluoroborates


A palladium-catalyzed enantioselective three-component reaction of glyoxylic acid, sulfonamides and aryl trifluoroborates is described. This process provides modular access to the important alpha-arylglycine motif in moderate to good yields and enantioselectivies. The formed alpha-arylglycine products constitute useful building blocks for the synthesis of peptides or arylglycine-containing natural products.


Supplementary material

Supporting Information
Experimental procedures, analytical data and copies of NMR spectra and HPLC chromatograms