15 March 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Deep Eutectic Solvents (DESs) are a class of solvents that are increasing their relevance in the research activity thanks to their environmental-friendly features as well as to their structural characteristics and catalytic properties. Formed by no-solvent mixing of two substances, namely a hydrogen bond donor and a hydrogen bond acceptor, DESs are finding fruitful applications in many different topics as alternatives to common organic compounds. In this work the realization, the characterization and the solubility applications of a novel water- based class of DESs are proposed. These innovative liquids, called aquo-DESs, are binary mixtures of water with glycolic acid (GA) and with trimethylglycine (TMG): GA/H2O (1/4 molar ratio) and TMG/H2O (1/5 molar ratio). The DES identity of these mixtures was demonstrated by: shifts both in terms of the molar fraction and of the melting points in the experimental melting point curves from the theoretical ones; amounts of components over their reported maximum solubility in water; thermogravimetric profiles compared to the pure substances. The aquo-DESs were characterized in their viscosity and ionic conductivity in the temperature range 20-55 C, showing really low viscosity and low ionic conductivity, with a peculiar behavior of the ionic conductivity of GA/H2O DES. The solubilizing properties of aminoacids, phenols and carboxylic acids showed peculiar really high values whenever the solute can participate to the DES as DES component itself.


Deep Eutectic Solvents (DESs)
water-based DESs
green solvents
physical properties.


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