Carbohydrate-DNA Conjugation Enabled by Glycosyl Radicals Generated from Glycosyl Sulfinates

09 March 2023, Version 2
This content is a preprint and has not undergone peer review at the time of posting.


Herein, we report a method that enables the synthesis of carbohydrate-DNA conjugates by radical addition, in which the gen-eration of glycosyl radicals from readily available and bench-stable unprotected glycosyl sulfinates is the key. These reactions were carried out under mild conditions and tolerate a broad substrate scope.


DNA-encoded libraries


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