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Enantioselective Total Synthesis of (+)-KB343

23 February 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A concise total synthesis of the complex guanidinium toxin KB343 is reported traversing through an unusual sequence of chemoselective transformations and strategic skeletal reorganization. The absolute configuration is confirmed through an enantioselective route and the structures of all key intermediates and the natural product itself are unassailably confirmed through X-ray crystallographic analysis.

Supplementary materials

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supporting information
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experimental procedures, characterizations of new compounds and X-ray datas
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Version History

Feb 23, 2023 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-cggfw
D O I: 10.26434/chemrxiv-2023-cggfw [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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