Structure Guided Design of VANOL-imidodiphosphorimidate Catalysts for the Catalytic Enantioselective Bromo Spiroketalization Reaction

24 February 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


This report presents a structure-guided approach for the optimization of VANOL-derived imidodiphosphorimidates as catalysts for the halonium-ion-induced spiroketalization reaction. Fine tuning of the catalyst active site, alongside enhanced acidity, were required to achieve high catalytic activity for the spiroketalization reaction. A wide range of substrates were well tolerated yielding halogenated spiroketals in high yields, diastereoselectivities, and enantioselectivities.


Brønsted acid catalyst
Nucleophile Assisted Alkene Activation
Imidodiphosphorimidate Catalysts

Supplementary materials

Supporting Information
Description of experimental procedures and characterization data


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.