I(III)-Mediated Oxidation of Anilines to Construct Dibenzazepines

17 February 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The development of an efficient process that produces bioactive medium-sized N-heterocyclic scaffolds from 2-substituted anilines using an iodine(III)-oxidant is reported. Construction of the medium-sized ring is mild, occurs at room temperature, and proceeds via cationic reactive intermediates.

Keywords

dibenzazepine
dibenzazocine
nitrenium ion
medium-ring formation

Supplementary materials

Title
Description
Actions
Title
Supporting Information for I(III)-Mediated Oxidation of Anilines to Construct Dibenzazepines
Description
Experimental Procedures, Characterization, and NMR Spectral Data for the compounds reported
Actions

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