Photochemical synthesis of acyl fluorides using copper-catalyzed fluorocarbonylation of alkyl iodides

14 February 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Acyl fluorides are important reagents in organic synthesis due to their unique balance between reactivity and stability. Here, we report a copper-catalyzed carbonylative coupling strategy to synthesize acyl fluorides under photoirradiation. Various alkyl halides were transformed in high yields into corresponding acyl fluorides by using a commercially available copper catalyst (CuBrSMe2) and a readily available fluoride salt (KF) at room temperature and mild CO pressure (6 atm) under blue light irradiation. A radical fluorocarbonylation mechanism is proposed based on experimental data.


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