Transmembrane Transport of Fluoride Studied by Time-Resolved Emission Spectroscopy

10 February 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Anion carriers are developed for their potential biological applications, including antibacterial properties. However, only a few fluoride carriers have been reported and no reliable spectroscopic method exists for the study of fluoride transport in liposomes. Here we present the use of an encapsulated europium(III) complex to monitor fluoride transport. We take advantage of the long emission lifetime of this probe to use time-resolved emission spectroscopy to study fluoride transport by a fluorescent phosphonium borane. Furthermore, the high sensitivity, selectivity, and versatility of the assay allowed us to study different types of fluoride transporters and unravel their mechanisms of action. This revealed the phosphonium borane and the bambusuril to be active as F-/Cl- antiporters, and the antimony-based compound to be a more efficient OH-/Cl- antiporter, while demonstrating the power of lanthanide probes for studying anion transport.


anion transport
transmembrane transport
lanthanide probe
time-resolved emission

Supplementary materials

Supporting Information
Experimental procedures and additional experimental data


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.