Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Gram-Scale Electrosynthesis of Protected Dehydroamino Acids

09 February 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A NaCl-mediated electrochemical oxidation of amino acid carbamates (R1 = Boc, Cbz) afforded alpha-methoxylated alpha-amino acids. Subsequent acid-catalyzed elimination delivered valuable dehydroamino acid derivatives. The simplicity of our open-to-air setup using simple graphite-electrodes submerged in a beaker was showcased producing N-Boc--Delta-Ala-OMe on decagram scale.

Supplementary materials

Title
Description
Actions
Title
Supporting Info
Description
Experimental Section
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Feb 09, 2023 Version 1

Metrics

742
528
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-806l4
D O I: 10.26434/chemrxiv-2023-806l4 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share