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Gram-Scale Electrosynthesis of Protected Dehydroamino Acids

09 February 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A NaCl-mediated electrochemical oxidation of amino acid carbamates (R1 = Boc, Cbz) afforded alpha-methoxylated alpha-amino acids. Subsequent acid-catalyzed elimination delivered valuable dehydroamino acid derivatives. The simplicity of our open-to-air setup using simple graphite-electrodes submerged in a beaker was showcased producing N-Boc--Delta-Ala-OMe on decagram scale.

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Version History

Feb 09, 2023 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-806l4
D O I: 10.26434/chemrxiv-2023-806l4 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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