Palladium responsive liposomes for triggered release of aqueous contents

30 January 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Palladium (Pd) is a promising metal catalyst for novel bioorthogonal chemistry and prodrug activation This report describes the first example of palladium responsive liposomes. The key molecule is a new caged phospholipid called Alloc-PE that forms stable liposomes (large unilamellar vesicles, ~220 nm diameter). Liposome treatment with PdCl2 removes the chemical cage, liberates membrane destabilizing dioleoylphosphoethanolamine (DOPE), and triggers liposome leakage of encapsulated aqueous contents. The results indicate a path towards liposomal drug delivery technologies that exploit transition metal trig-gered leakage.


Caged phospholipid
fluorescent liposome leakage

Supplementary materials

Supporting Data
Experimental procedures, synthesis and compound characterization, supplementary figures


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