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Nickel Catalyzed Cross Coupling of Aryl and Alkenyl Triflates with Alkyl Thiols

20 January 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report a nickel catalyzed C-S cross-coupling of aryl and alkenyl triflates with alkyl thiols. A variety of the corresponding thioethers were synthesized using an air-stable nickel precatalyst under mild reaction conditions with short reaction times. A broad substrate scope, including pharmaceutically relevant compounds, could be demonstrated.

Keywords

thioether
coupling
nickel catalysis
triflate

Supplementary materials

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Description
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Supporting Information
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Experimental and spectral data
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Version History

Jan 20, 2023 Version 1

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BY
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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-7632g
D O I: 10.26434/chemrxiv-2023-7632g [opens in a new tab]

Funding

Deutsche Forschungsgemeinschaft
FL 878/9-1

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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