The First Total Synthesis of Tanzawaic Acid B

18 January 2023, Version 3


The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the chiral octalin that possesses seven stereogenic centers and that is the core skeleton of almost all of the tanzawaic acid family.


Total Synthesis
Tanzawaic Acids
Tanzawaic Acid B
Intramolecular Diels–Alder Reaction
Gram-scale Synthesis

Supplementary materials

The First Total Synthesis of Tanzawaic Acid B_SI
The synthetic procedures and NMR spectra were herein.


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