Competitive Aminal Formation during the Synthesis of a Highly Soluble, Isopropyl-Decorated Imine Porous Organic Cage

05 January 2023, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The synthesis of a new porous organic cage decorated with isopropyl moieties (CC21) was achieved from the reaction of triformylbenzene and an isopropyl functionalised diamine. Unlike structurally analogous porous organic cages, its synthesis proved challenging due to competitive aminal formation, rationalised using control experiments and computational modelling. The use of an additional amine was found to increase conversion to the desired cage.


Porous organic cages
Dynamic covalent chemistry

Supplementary materials

Supporting Information
Includes experimental procedures, characterisation data, and computational details.


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