![Author ORCID: We display the ORCID iD icon alongside authors names on our website to acknowledge that the ORCiD has been authenticated when entered by the user. To view the users ORCiD record click the icon. [opens in a new tab]](https://chemrxiv.org/engage/assets/public/chemrxiv/images/logos/orcid.png)
Abstract
Togni reagent II is a synthetically useful hypervalent iodine reagent for direct trifluoromethylation. Herein, we report a new reaction of Togni reagent II: α-C–H ester-functionalization of tertiary amides. This α-acyloxylation reaction proceeds smoothly in the presence of a mild base at 25–30 oC and produces moderate-to-high yields. This newly discovered reaction adds another dimension to the utility of Togni reagent II and provides direct and easy access to α-acyloxy amides and α-hydroxy amides.
Supplementary materials
Title
Supporting Information
Description
Experimental procedures, full characterization of all prepared compounds, and copies of all spectral data.
Actions
