The combination of activated carboxylic acids and alcohols or amines to access esters and amides, respectively, is a cornerstone of organic chemistry and has been well developed over the past century. These dehydrations are extensively used in medicinal chemistry and natural product synthesis due to the prevalence of these functional groups in bioactive molecules. Here, we report a divergent process from the expected ester/amide outcomes through a light-induced coupling of activated carboxylic acids and alcohols/amines to efficiently prepare -hydroxy/amino ketones or -ketophosphonates via single-electron chemistry. A phosphorus linchpin strategy allows for the combination of these simple reagents through an intramolecular triplet state radical process, thereby enabling new carbon-carbon bond formation.
Visible Light-Induced Coupling of Carboxylic Acids with Alcohols and Amines
15 December 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.