Switching nitrofurantoin polymorphic outcome in solvent mediated phase transformation and crystallization using solvent and additives

15 December 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Several additives and solvent allow reversing the polymorphic outcome of solvent mediated phase transformation experiments and crystallization, as well as the apparent relative solubility of polymorphs of the antibacterial drug nitrofurantoin.


Pharmaceutical polymorphism
solvent mediated phase transformations
thermodynamic stability

Supplementary materials

Switching nitrofurantoin polymorphic outcome ESI
Experimental details, Evaluation of relative stability of nitrofurantoin polymorphs, Crystal form outcome of crystallization, Nucleation induction times, Speciation in solution, Analysis of crystal structures and morphology of nitrofurantoin polymorphs, Characterization of α obtained in the crystallization from acetonitrile in presence of BIS-TRIS


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