Thermal Analysis of Arenediazonium Tetrafluoroborate Salts: Stability and Hazardous Evaluation

30 November 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Arenediazonium salts represent an important class of aromatic organic compounds widely used as building blocks in academia and industry. Due to the high energy associated with the diazonium group, many of these salts are reported as thermally unstable and/or unsafe to work with. However, most of the tetrafluoroborate arenediazonium salts, are fairly stable to handle at room temperature both in solution and when dry. Nevertheless, some of these salts, especially those containing heteroatoms in the aromatic moiety, present difficulties in their synthesis, and some are indeed highly unstable. To bring some light to this controversial subject, the thermal stability and potential hazards of the 57 most common arenediazonium tetrafluoroborate salts used in our laboratory over the last two decades were evaluated under careful conditions. These results are expected to guide important decisions on the use of arenediazonium tetrafluoroborates in organic synthesis.

Keywords

arenediazonium tetrafluoroborates
thermal analysis
Differential Scanning Calorimetry
Impact Sensitivity

Supplementary materials

Title
Description
Actions
Title
Thermal Analysis of Arenediazonium Tetrafluoroborate Salts: Stability and Hazardous Evaluation
Description
The Supplementary Material contains the general procedure for the synthesis of the arenediazonium tetrafluoroborates, the data concerning the Differential Scanning Calorimetry analyses, the Prediction of Impact Sensitivity (IS), and Explosion Propagation (EP) Hazards based on Yoshida, and the Pfizer Correlations, and Estimated Maximum Recommended Process Temperatures (TD24).
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.