A Novel Scaffold for Nitric Oxide Photo-Releasers based on Meso-Aminomethyl-BODIPY

Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Its short half-life and local action impede direct application in medicine because highly targeted NO-delivery systems are required. Light-controllable NO releasers are promising for the development of smart therapies. Here we present novel simply prepared meso-aminomethyl BODIPY dyes containing N-Nitroso moiety and show the photoinduced generation of NO in a solution. As an example of NO-mediated effects, we demonstrate efficient light-dependent inhibition of platelet activation in vitro. We also show that some compounds could additionally generate singlet oxygen, which is promising for the photodynamic therapy. The presented compounds could serve as the basis for the development of novel hybrid therapeutic methods.