Synthesis of γ-alkenylated δ-sultones via Brønsted base-catalyzed Michael addition-SuFEx click reaction of allyl ketones and ethenesulfonyl fluorides

17 November 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A tandem annulation reaction of allyl ketones and ethenesulfonyl fluoride has been described. Under the catalysis of Brønsted base, vinyl ketones reacted with ethenesulfonyl fluoride through a cascade intermolecular Michael addition-intramolecular SuFEx process to afford γ-alkenylated δ-sultones in good to excellent reaction yields. In this reaction, no additional base was needed, and 4 Å Molecular sieves was used as efficient HF scavenger to restrict the neutralization and deactivation of the Brønsted base catalyst.

Keywords

tandem annulation reaction
Michael addition-intramolecular SuFEx
γ-alkenylated δ-sultones
ethenesulfonyl fluoride

Supplementary materials

Title
Description
Actions
Title
Construction of γ-alkenylated δ-sultones via Brønsted base-catalyzed tandem annulation reactions
Description
Synthesis of γ-alkenylated δ-sultones via Brønsted base-catalyzed Michael addition-SuFEx click reaction of allyl ketones and ethenesulfonyl fluorides
Actions

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