Palladium Catalyzed syn-1,2-ArylMethylation of Internal Alkynes

15 November 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A Pd-catalyzed syn-1,2-arylmethylation of internal alkynes (ynamides/ yne-acetates) is described. The readily available and bench stable coupling partners iodo-arenes, and methyl boronic acid are successfully being used to access the methyl containing tetra substituted olefins; notably, the transformation is regio as well stereoselective. The scope is broad (52 examples), showing excellent functional-group tolerance. Finally, synthetic manifestations of the products were also demonstrated.




Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.