Ligand-Free Ullmann-Type Arylation of Oxazolidinones by Diaryliodonium Salts

14 November 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The arylation of azaheterocycles can be considered as one of the most important processes for the preparation of various biologically active compounds. In the present work, we describe a method for the copper-catalyzed N-arylation of hindered oxazolidinones using diaryliodonium salts. The method succeeds in good to excellent yields for the arylation of 4-alkyloxazolidinones, including sterically hindered isopropyl- and tert-butyl-substituted representatives. The efficiency of the method was demonstrated for a wide range of diaryliodonium salts - symmetric and unsymmetric as well as ortho-substituted. The developed approach can provide an important contribution in the development and preparation of novel drugs and bioactive molecules containing oxazolidinone moieties.

Keywords

arylation
iodonium salts
copper catalyst
Ullmann-type arylation
oxazolidinones

Supplementary materials

Title
Description
Actions
Title
Ligand-Free Ullmann-Type Arylation of Oxazolidinones by Diaryliodonium Salts: ESI
Description
Supporting information
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