Abstract
A stereoselective synthesis of isoindolo[2,1-a]quinolin-11(5H)-ones containing three contiguous
stereogenic centers is described. This Lewis-acid mediated reaction of enamides with N-aryl- affords
the desired fused heterocyclic isoindolinones in high yields and diastereoselectivities. Scope and
limitations of this method are discussed. The stereochemical outcome of this transformation indicates
a stepwise reaction pathway.
Supplementary materials
Title
Supporting Information
Description
Experimental procedures, analytical data and copies of NMR spectra
Actions
Title
X-Ray data
Description
cif and checkcif files for compounds syn-11a, anti-11a, anti-11b, syn-11d, syn-11g, syn-11i and 12b (CCDC 2189964-2189970)
Actions